Human liver steroid sulphotransferase sulphates bile acids
نویسندگان
چکیده
منابع مشابه
Fatty liver diseases, bile acids, and FXR
The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide has increased at an alarming rate, which will likely result in enormous medical and economic burden. NAFLD presents as a spectrum of liver diseases ranging from simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even to hepatocellular carcinoma (HCC). A comprehensive understanding of the mechanism(...
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Total serum bile acid levels (TSBA) were determined in 44 patients with acute and chronic hepatic diseases. Elevated levels of TSBA were observed in all the patients. Values were higher in cirrhosis, lowest in liver cancer and intermediate in hepatitis. When compared with normal values a significant (p<0.001) increase in TSBA was found in three groups of patients. No significant correlation was...
متن کاملPurification and characterization of human liver dehydroepiandrosterone sulphotransferase.
A form of sulphotransferase capable of sulphating dehydroepiandrosterone and other steroids was purified from cytosol prepared from human liver. Dehydroepiandrosterone sulphotransferase was purified 621-fold when compared with the activity in cytosol using DEAE-Sepharose CL-6B and adenosine 3',5'-bisphosphate-agarose affinity chromatography. During affinity chromatography, dehydroepiandrosteron...
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Bile acids are endogenous molecules that originate from the liver and transport via bile to the intestines. They normally regulate cholesterol homeostasis, stimulate lipid solubilization and mediate metabolic signaling. Early studies implicated that disorders of bile acids compositions and concentrations can cause liver injury. Several hydrophobic bile acids are toxic and ample increases of the...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1990
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2720597